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Nanofiber-Hydrogel Loaded with Stem Cells Shows Success Treating Severe Complication of Crohn’s Disease



In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn’s disease.Get more news about best medical silicone gel cost,you can vist our website!

Crohn’s disease, a subtype of inflammatory bowel disease, is a disorder estimated by the U.S. Centers for Disease Control and Prevention to afflict more than three million adult Americans. About 30 percent to40 percent of patients with Crohn’s disease develop perianal fistulas — an inflamed tunnel between the skin and the inside of the anus. Fistulas can lead to pain, swelling, discomfort and leakage of blood or pus. Surgery is usually needed to treat the condition. However, more than half of patients do not benefit from current available treatments.

The injectable, biodegradable, mechanically fragmented nanofiber-hydrogel composite (mfNHC), loaded with stem cells that the Johns Hopkins team designed, can be injected inside the fistula tract, and showed a higher degree of healing, reducing the size of fistulas six-fold, in comparison to surgery.
A large number of patients are diagnosed with Crohn’s disease in their late teens to early 20s, and they are contemplating a lifetime of suffering from perianal fistulas,” says Florin M. Selaru, M.D., associate professor of medicine and oncology; director of the IBD Center at Hopkins and the Atran Professor in IBD Research at Johns Hopkins Medicine and one of the senior authors of the study. “This condition in Crohn’s patients is notoriously difficult to treat. We hope these results offer a potential new treatment paradigm to be translated and to improve the quality of life for these patients.”

Selaru says previous studies and current clinical trials have shown stem cell injection around fistula tracts have helped with local healing. However, the stem cells are unlikely to be retained around the fistula track for any meaningful duration of time that may allow for any significant healing. The hydrogel created by the team can be injected directly into the fistula tract. It is infused with nanofiber fragments that give the substance enough stiffness to anchor the stem cells in place at the site of the fistula, so they don’t migrate away. This will assist with tissue regeneration and promote healthy healing.

“Think of it as a local delivery of a tissue regeneration nanogel-nanofiber composite that also keeps the stem cells at the site of the injury and enables the healing to occur,” says Selaru. The gel built a scaffold that retained the stem cells at the site of the fistulas and promoted regenerative healing. Results showed the gel had an overall reduction in volume of the fistula track by six times, compared to surgery.

“These results are very exciting for the future of bio-stimulation tissue repair for chronic injuries — even beyond PAF,” says Hai-Quan Mao, Ph.D., professor in Whiting School of Engineering's Department of Materials Science and Engineering and Department of Biomedical Engineering, and another senior author of this study. Mao is also director of Johns Hopkins Institute for NanoBioTechnology.

Selaru cautions, however, that these very encouraging results need to be verified in human trials. The experiments conducted thus far have laid the foundation of such translational future studies. The team plans to continue this work and to improve the gel, including exploring the idea of a foam version.

Siemens Siplace DX Chip Mounter


SIPLACE's new DX series Pick and Place machine, high-performance equipment, and intelligent production solutions are the smart choices for customers.Get more news about siemens used mounter wholesale prices,you can vist our website!
Siemens Chip Mounter DX Series Features:
SIPLACE's new DX series inherits the many advantages of the SIPLACE series of platforms and combines new and innovative technology applications to provide customers with an integrated solution.
◆ The DX series achieves a very high processing capacity while providing a better cost performance and performance space ratio.
◆ Application of new technology to achieve high placement quality
The universal application of linear motor technology on DX equipment, full-closed loop control system, intelligent X feeder technology, and placement head design based on 01005 scale application ensure long-term accuracy and various technical indicators of SIPLACE DX series. Both are in the leading position in the industry and have achieved high production quality in the industry.
◆ Intelligent feeding, production and changeover solutions
Not only advanced equipment for the benefit of customers, but also with the innovation of SIPLACE software, allowing customers to easily achieve intelligent loading, production and change lines. For example, the DX series offers more feeder levels, and its unique Split table virtual material trolley technology can help customers easily achieve multi-product collinear production and material management, and achieve high efficiency of equipment.
◆ Fast new product import function
Not only can virtual production and offline confirmation on the programming machine, but also component picking and placement position learning on the machine, with the industry's advanced digital visual recognition system and simpler production operations, the introduction of fast new products.

Are Biodegradable Fabrics the Future of Workwear?



As both businesses and consumers seek to be more eco-friendly, products and services that were previously overlooked by those wanting to be greener are starting to come to the fore.Get more news about workwear fabric suppliers,you can vist our website!

Being green is no longer just about Meatless Monday or rinsing out the recycling, it’s also trickling down into the choices we make regarding everything from where we holiday to rejecting fast fashion.

Fast fashion retailers turn around catwalk-inspired clothing in as quick a time as possible, and as cheaply as they can. The knock-on effect of this is more pollution and more low-quality clothing ending up in landfill.

However, when it comes to workwear, increasing the life of garments is key. Businesses don’t want to replace overalls and PPE every couple of months: the costs involved would be prohibitive. Besides, what company wants to buy cheaply made workwear that’s not fit for purpose?
The rise of biodegradable workwear

The fashion industry has been using biodegradable fabrics for some time now, with many retailers using their environmentally friendly processes and materials as a marketing tool.

Now organizations who provide workwear to their employees are catching on too as companies with a conscience strive to adopt more ethical practices.

Limiting their impact on the planet is increasingly at the top of the agenda for many business leaders and using biodegradable fabrics in their workwear is part of that.

What are biodegradable fabrics?

A biodegradable fabric uses microorganisms to decompose more easily than non-biodegradable cloth. Clothing is made from natural textiles such as wool, organic cotton, hemp, linen, bamboo, and jute.

In addition, viscose-based fabrics such viscose rayon, lyocell and cupro are normally biodegradable despite having their chemical structure artificially altered, as they originate from cellulose.

A fabric’s biodegradability is measured by the amount of chemicals used during its manufacture. The more chemicals used, the longer it takes for an item of clothing to biodegrade. And the longer this process takes, the more harmful the effect on the environment.

What can your business do to be greener?

There are plenty of actions that businesses of all sizes can take to reduce your carbon footprint

Recycling workwear, making sure ex-employees return clothing and PPE so it can be reworn, buying British to lower transport emissions, buying quality gear that will last, and opting for workwear made from biodegradable fabrics are all actionable ideas that will have a positive impact.

Pneumatic vs. Electric Sanders



Firstly, I absolutely love your show. The reason I am writing is that I have been watching David Marks Woodworks and noticed in a couple of his episodes he uses a pneumatic power sander. There is not much literature on the web regarding these machines. I was wondering if maybe you could highlight some of the characteristics of these machines. Watching the video I could not see any visible dust collection and all I could gather about these machines is they are more powerful than the electric sanders. Get more news about air palm sander factory,you can vist our website!

To be completely honest, I actually don’t have a whole lot of experience with pneumatic sanders. In fact, the only time I used one was in David’s shop. But I can still give you a some things to think about. There are a few key differences between pneumatic and electric sanders that may or may not matter to you. Pneumatics are generally lighter. After all, there’s no motor. As a result, they can also be quieter and longer lasting. The tools themselves are usually much cheaper too. That is, on a tool for tool basis they are cheaper (again, no motor). But obviously to use a pneumatic tool, you’re gonna need a big daddy air compressor. The smaller units will cycle repeatedly which will ultimately kill the compressor. And from what I hear, pneumatic sanders can also be more powerful than our standard electric sanders.

Now one big disadvantage that I see is the one you mentioned: dust collection. Although I have seen a few models on the market that have a connector for the dust. For most of us these days, good dust collection is a must-have. So that’s something to keep in mind. Ultimately, if you already own a big compressor, or if you envision yourself using other air-sucking tools like die grinders, air guns, and conversion spray guns, the pneumatics might just be a good choice.

The Best Memory Foam Pillows



A good night’s sleep is essential if you want to wake up feeling refreshed and ready to tackle the day, and a memory foam pillow can help you get the restful sleep you deserve. These pillows have become increasingly popular due to their superior comfort and support. Their foam material is designed to conform to the shape of your head and neck, properly aligning your body and offering gentle support as you sleep. In this post, we’ll take a closer look at some of the most popular memory foam pillows of 2023. We’ll also share our buying tips so you’ll know exactly what to look for while shopping for a contouring foam pillow. Whether you’re a side sleeper, a back sleeper, or a stomach sleeper, there’s a pick out there that’s perfect for you.Get more news about oem sponge pillow,you can vist our website!
Buying Guide: Memory Foam Pillows
There are several important factors to consider when purchasing a memory foam pillow. In this comprehensive shopping guide, we will walk you through these considerations so you will have all the information you need to make an informed decision.

Firmness
One of the most important factors to consider when shopping for a foam pillow is firmness. A pillow that is too firm can be uncomfortable, while one that is too soft won’t provide enough support. Choose a pillow that offers the right balance between support and comfort for your individual needs.

Most shredded foam pillows allow you to adjust the loft by adding or removing filling according to your comfort and preferences.

Density
Your pillow’s density is also important. Pillows with higher-density foam will provide more support and last longer than those with lower-density foam. Check the reviews to make sure the pillow you’re considering will retain its shape well over time.

Size
You’ll also want to consider the pillow’s size and shape to ensure it fits your body, preferred sleep position(s), and bed.

Breathability
Look for a memory foam pillow constructed with breathable materials such as perforated memory foam or open-cell memory foam. This will help to keep you cool while you sleep by allowing air to circulate through the pillow.

Odor
New foam pillows can sometimes have an unpleasant smell, but don’t let this put you off, as the odor typically wears off shortly after unpacking. You can also simply look for a product with little or no odor by checking the product’s listing and reviews.

Behind the Scene: Rear vs. Front Projection


Rear projection used to be the holy grail of projection. The idea is that by putting the projector behind the screen, in its own room or space where ambient light hitting the back of the screen can be contained and controlled, you can achieve the best image. This also helps to make the image more resilient to ambient light that may be hitting the front of the screen.Get more news about best price rear projection,you can vist our website!

One of my main issues with rear projection is that by using rear projection screen material, you reflect a lot of the brightness back toward the projector. This results in a significant loss of brightness, which means you'll have to spend more money for a projector that can provide even higher brightness than the image brightness you need. Another concern is the space required behind the screen for the projector to throw the correct size image.
Of course, front projection comes with its own set of problems. First, you traditionally have to hang the projector from the ceiling somewhere out in the room, which can be unsightly. And, of course, ambient light can wash out the image on your screen. One workaround for the first issue—an obtrusive installation—can be solved with the selection of a long zoom lens that allows you to put the projector at the back of the room. However, these lenses are quite expensive, which only adds to the cost.

So which approach is the right one for your space? The answer, not surprisingly is: it depends. There really isn't one solution that is right for every space and budget. However, there are some ways you can quickly determine which option might be best suited for your application.
Rear Projection Pros & Cons
Rear projection can take quite a bit of valuable space away from the facility; a room must be dedicated for the use, and that means a loss of classroom and/or storage space. In older facilities stretched on space to begin with, that can be a serious concern.

As mentioned, the throw distance can also be a challenge, even when there exists what seems like a reasonable space to dedicate to the installation. Fortunately, there are some very clever systems that have been developed to help alleviate the sometimes shocking throw distance requirements for rear projection. These complex systems use one or more mirrors to bounce the image around in order to achieve the necessary distance for a given screen size. However, this introduces more potential points of failure, as even a small shift in one of these mirrors can result in a need to re-calibrate the entire system.

Rear projection screen materials can cost more money than front projection screens, as well. The technology employed by rear projection screens can cost more in research and development and manufacturers must recoup those costs, usually in the form of a higher price tag. (You can learn more about rear projection screen options at ProjectorCentral's Projector Screen Suppliers page.)

Nonetheless, for those of you who have facilities that can accommodate a rear projection setup, it is definitely worth looking into, especially for situations that require a high value placed on aesthetics and hiding as much of the technology as possible.

Along those lines, another situation where rear projection could prove useful is where noise levels may be an issue. Projector fans, especially on high brightness projectors, are not usually the quietest, and places like museums, theaters, and churches can benefit from reduced ambient noise levels by hiding the projectors away in another room.

Ultimately, then, it comes down to what your facility will allow. Do I think having rear projection is worth the cost of remodeling your facility to accommodate it? Not usually. I would say that 95 percent of the time, you can achieve similar, if not superior, results with front projection for the same, if not less, investment.

One reason for that is the wide range of ALR screens now available. With the multiple options currently on the market and the plethora of low cost, bright, high resolution projectors that have also emerged, there's typically very little reason anymore to look seriously at rear projection. Does that mean it's not a viable solution? No, but it will not produce a significantly better image than a front projection system that incorporates a properly matched projector and screen combination.

Double Sided Foam Tape Offers A Superior Alternative To Other Adhesive Products



Double sided foam tapes have become increasingly popular in recent years, thanks to their versatility, ease of use, and durability. These tapes consist of two layers of adhesive, sandwiching a foam core, making them ideal for a range of applications, including bonding, mounting, and sealing.Get more news about high quality acrylic foam tape,you can vist our website!

In this article, we will explore the key features of double sided foam tapes, their types, applications, and benefits.

Double sided foam tapes have a number of key features that make them stand out from other adhesive products. These include:

1. High tack and adhesion – Double sided foam tapes are highly sticky, providing strong bonding power to a variety of surfaces.

2. Flexibility – The foam core in double sided foam tapes makes them highly flexible, allowing easy conformability to curved or uneven surfaces.

3. Weather resistance – Many double sided foam tapes are designed to resist harsh weather conditions, including extreme temperatures, moisture, and UV radiation.

4. Shock absorption – Double sided foam tapes are ideal for cushioning and shock absorption, thanks to the foam core.

Double sided foam tapes come in different types, each with unique properties and applications. The most common types include:

1. Acrylic foam tapes – These tapes employ acrylic adhesive, which provides high resistance to heat and UV radiation. They are commonly used in the automotive, electronics, and construction industries.

2. Rubber foam tapes – These tapes use rubber adhesive, which provides superior bonding power and is ideal for mounting and sealing. They are commonly used in signage, graphics, and advertising.

3. Silicone foam tapes – These tapes use silicone adhesive, which boasts high performance at extremely low and high temperatures. They are ideal for aerospace, automotive, and semiconductor industries.
Double sided foam tapes are used in a wide range of applications, including:

1. Automotive – Double sided foam tapes are used for bonding, mounting, and sealing automotive parts, such as emblems, trims, and weatherstrips.

2. Electronics – Double sided foam tapes are used for mounting and securing electronic components, such as circuit boards, displays, and sensors.

3. Construction – Double sided foam tapes are used for mounting and sealing construction materials, such as glass, metal, and plastic.

4. Signage and graphics – Double sided foam tapes are used for mounting and displaying signs, banners, and posters.